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Article

Long-term evolution of the epithelial cell secretome in preclinical 3D models of the human bronchial epithelium

23 Mar 2021

Abstract excerpt

The human bronchial epithelium is the first line of defense against atmospheric particles, pollutants, and respiratory pathogens such as the novel SARS-CoV-2. The epithelial cells form a tight barrier and secrete proteins that are major components of the mucosal immune response. Functional in vitro models of the human lung are essential for screening the epithelial response and assessing the toxicity and barrier...

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PMID: 33758289
DOI: 10.1038/s41598-021-86037-0

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