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Investigation of Burkholderia cepacia Complex Methylomes via Single-Molecule, Real-Time Sequencing and Mutant Analysis.

Journal of bacteriology - 20 May 2021

Mannweiler Olga, Pinto-Carbó Marta, Lardi Martina, Agnoli Kirsty, Eberl Leo

Abstract excerpt

Bacterial genomes can be methylated at particular motifs by methyltransferases (MTs). This DNA modification allows restriction endonucleases (REs) to discriminate between self and foreign DNA. While the accepted primary function of such restriction modification (RM) systems is to degrade incoming foreign DNA, other roles of RM systems and lone RE or MT components have been found in genome protection, stability,...

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PMID: 33753468
DOI: 10.1128/JB.00683-20
PMCID: PMC8316024

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