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Correlation of methylation status in MTHFR promoter region with recurrent pregnancy loss

22 Mar 2021

Abstract excerpt

BACKGROUND: DNA methylation is an epigenetic process for modifying transcription factors in various genes. Methylenetetrahydrofolate reductase (MTHFR) stimulates synthesis of methyl radical in the homocysteine cycle and delivers methyl groups needed in DNA methylation. Furthermore, numerous studies have linked gene polymorphisms of this enzyme with a larger risk of recurrent pregnancy loss (RPL), yet scarce...

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PMID: 33751263
DOI: 10.1186/s43141-021-00147-w

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