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Article

An intronic DHCR7 genetic polymorphism associates with vitamin D serum level and incidence of acute coronary syndrome.

Steroids - 1 May 2021

Elbehairy Mariam M, Abdelnasser Hala Y, Hanafi Rasha S, Hassanein Sally I, Gad Mohamed Z

Abstract excerpt

INTRODUCTION: Vitamin D deficiency has been linked to cardiovascular pathologies including acute coronary syndrome (ACS). Polymorphisms in vitamin D associated genes have been confounding to vitamin D serum levels and pathological predispositions. 7-hydrocholesterol is a common precursor in cholesterol and vitamin D synthesis. DHCR7/NADSYN1 genetic locus expresses 7-hydrocholesterol reductase (DHCR7), an enzyme...

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PMID: 33741398
DOI: 10.1016/j.steroids.2021.108825

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