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Article

Dualmarker: a flexible toolset for exploratory analysis of combinatorial dual biomarkers for clinical efficacy.

BMC bioinformatics - 17 Mar 2021

Ma Xiaopeng, Huang Ruiqi, Wu Xikun, Zhang Pei

Abstract excerpt

BACKGROUND: An increasing number of clinical trials require biomarker-driven patient stratification, especially for revolutionary immune checkpoint blockade therapy. Due to the complicated interaction between a tumor and its microenvironment, single biomarkers, such as PDL1 protein level, tumor mutational burden (TMB), single gene mutation and expression, are far from satisfactory for response prediction or...

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Identifiers

PMID: 33731020
DOI: 10.1186/s12859-021-04050-6
PMCID: PMC7972341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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