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Article

Lineage-specific selection and the evolution of virulence in the Candida clade.

Proceedings of the National Academy of Sciences of the United States of America - 23 Mar 2021

Singh-Babak Sheena D, Babak Tomas, Fraser Hunter B, Johnson Alexander D

Abstract excerpt

Candida albicans is the most common cause of systemic fungal infections in humans and is considerably more virulent than its closest known relative, Candida dubliniensis. To investigate this difference, we constructed interspecies hybrids and quantified mRNA levels produced from each genome in the hybrid. This approach systematically identified expression differences in orthologous genes arising from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33723044
DOI: 10.1073/pnas.2016818118
PMCID: PMC8000421

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