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Comparative genomics using Candida albicans DNA microarrays reveals absence and divergence of virulence-associated genes in Candida dubliniensis.

Microbiology (Reading, England) - 1 Oct 2004

Moran Gary, Stokes Cheryl, Thewes Sascha, Hube Bernhard, Coleman David C, Sullivan Derek

Abstract excerpt

Candida dubliniensis is a pathogenic yeast species closely related to Candida albicans. However, it is less frequently associated with human disease and displays reduced virulence in animal models of infection. Here comparative genomic hybridization was used in order to assess why C. dubliniensis is apparently less virulent than C. albicans. In these experiments the genomes of the two species were compared by...

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PMID: 15470115
DOI: 10.1099/mic.0.27221-0

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