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Article

The SARS-CoV-2 Y453F mink variant displays a pronounced increase in ACE-2 affinity but does not challenge antibody neutralization.

The Journal of biological chemistry - 1 Jan 2000

Bayarri-Olmos Rafael, Rosbjerg Anne, Johnsen Laust Bruun, Helgstrand Charlotte, Bak-Thomsen Theresa, Garred Peter, Skjoedt Mikkel-Ole

Abstract excerpt

Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 from humans to animals has been reported for many domesticated species, including farmed minks. The identification of novel spike gene mutations appearing in minks has raised major concerns about potential immune evasion and challenges for the global vaccine strategy. One genetic variant, known as "cluster five," arose among farmed minks in Denmark...

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Share to Angiotensin-Converting Enzyme 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33716040
DOI: 10.1016/j.jbc.2021.100536
PMCID: PMC7948531

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