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Article

Global REACH 2018: dysfunctional extracellular microvesicles in Andean highlander males with excessive erythrocytosis.

American journal of physiology. Heart and circulatory physiology - 1 May 2021

Brewster L Madden, Bain Anthony R, Garcia Vinicius P, Fandl Hannah K, Stone Rachel, DeSouza Noah M, Greiner Jared J, Tymko Michael M, Vizcardo-Galindo Gustavo A, Figueroa-Mujica Romulo J, Villafuerte Francisco C, Ainslie Philip N, DeSouza Christopher A

Abstract excerpt

High altitude-related excessive erythrocytosis (EE) is associated with increased cardiovascular risk. The experimental aim of this study was to determine the effects of microvesicles isolated from Andean highlanders with EE on endothelial cell inflammation, oxidative stress, apoptosis, and nitric oxide (NO) production. Twenty-six male residents of Cerro de Pasco, Peru (4,340 m), were studied: 12 highlanders...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33710927
DOI: 10.1152/ajpheart.00016.2021
PMCID: PMC8163655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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