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Article

SENP1, but not fetal hemoglobin, differentiates Andean highlanders with chronic mountain sickness from healthy individuals among Andean highlanders.

Experimental hematology - 1 Jun 2016

Hsieh Matthew M, Callacondo David, Rojas-Camayo Jose, Quesada-Olarte Jose, Wang Xunde, Uchida Naoya, Maric Irina, Remaley Alan T, Leon-Velarde Fabiola, Villafuerte Francisco C, Tisdale John F

Abstract excerpt

Chronic mountain sickness (CMS) results from chronic hypoxia. It is unclear why certain highlanders develop CMS. We hypothesized that modest increases in fetal hemoglobin (HbF) are associated with lower CMS severity. In this cross-sectional study, we found that HbF levels were normal (median = 0.4%) in all 153 adult Andean natives in Cerro de Pasco, Peru. Compared with healthy adults, the borderline elevated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26952840
DOI: 10.1016/j.exphem.2016.02.010
PMCID: PMC6471513

Genes

SENP1
EGLN1
EPAS1
EPO
JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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