Article

Assessment of ecological fidelity of human microbiome-associated mice in observational studies and an interventional trial

2025-03-11

Abstract excerpt

Composition and function of the gut microbiome is associated with diverse health conditions and treatment responses. Human microbiota-associated (HMA) mouse models are used to establish causal links for these associations but have important limitations. We assessed the fidelity of HMA mouse models to recapitulate ecological responses to a microbial consortium using stools collected from a human clinical trial. HMA...

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Literature Corpus work: 6d8e4609-8953-5d3a-95a3-05036676729a
DOI: 10.1101/2025.03.11.642547

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