Article
Detection of a SARS-CoV-2 variant of concern in South Africa.
Nature - 1 Apr 2021
Tegally Houriiyah, Wilkinson Eduan, Giovanetti Marta, Iranzadeh Arash, Fonseca Vagner, Giandhari Jennifer, Doolabh Deelan, Pillay Sureshnee, San Emmanuel James, Msomi Nokukhanya, Mlisana Koleka, von Gottberg Anne, Walaza Sibongile, Allam Mushal, Ismail Arshad, Mohale Thabo, Glass Allison J, Engelbrecht Susan, Van Zyl Gert, Preiser Wolfgang, Petruccione Francesco, Sigal Alex, Hardie Diana, Marais Gert, Hsiao Nei-Yuan, Korsman Stephen, Davies Mary-Ann, Tyers Lynn, Mudau Innocent, York Denis, Maslo Caroline, Goedhals Dominique, Abrahams Shareef, Laguda-Akingba Oluwakemi, Alisoltani-Dehkordi Arghavan, Godzik Adam, Wibmer Constantinos Kurt, Sewell Bryan Trevor, Lourenço José, Alcantara Luiz Carlos Junior, Kosakovsky Pond Sergei L, Weaver Steven, Martin Darren, Lessells Richard J, Bhiman Jinal N, Williamson Carolyn, de Oliveira Tulio
Abstract excerpt
Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus1,2. Here we describe a newly arisen lineage of SARS-CoV-2 (designated 501Y.V2; also known as B.1.351 or 20H) that is defined by eight mutations in the spike protein, including three substitutions (K417N, E484K and N501Y) at residues in its receptor-binding domain...
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