Article
The fat mass and obesity-associated (FTO) gene allele rs9939609 and glucose tolerance, hepatic and total insulin sensitivity, in adults with obesity.
PloS one - 1 Jan 2021
de Soysa Ann Kristin Hjelle, Langaas Mette, Jakic Anida, Shojaee-Moradie Fariba, Umpleby A Margot, Grill Valdemar, Mostad Ingrid Løvold
Abstract excerpt
The objective of the study was to assess associations of the rs9939609 FTO allele to glucose tolerance, hepatic and total insulin sensitivity (IS) in individuals with obesity. From a low-dose hyperinsulinemic euglycemic clamp with glucose-tracer, hepatic IS was assessed by rates of basal and suppressed glucose appearance (Ra), a measure of endogenous glucose production (EGP), and the hepatic insulin resistance...
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