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Article

Examining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention.

Breast cancer research and treatment - 1 Jun 2021

Nguyen ThaiHien, Irwin Melinda L, Dewan Andrew T, Cartmel Brenda, Harrigan Maura, Ferrucci Leah M, Sanft Tara, Li Fangyong, Lu Lingeng, Salinas Yasmmyn D

Abstract excerpt

PURPOSE: Our study examined whether common variants of obesity-associated genes FTO, MC4R, BDNF, and CREB1 moderated the effects of a lifestyle intervention on weight change among breast cancer survivors. METHODS: 151 breast cancer survivors with a body mass index ≥ 25 kg/m2 were randomly assigned to a 6-month weight loss intervention or usual care group. Genotyping of FTO rs9939609, MC4R rs6567160, BDNF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide
Share to Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Share to Body Mass Index
Share to Breast Neoplasms
Share to Cancer Survivors
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Share to Obesity
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Source

Identifiers

PMID: 33677781
DOI: 10.1007/s10549-021-06151-5

Genes

BDNF
FTO
MC4R

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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