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IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection

5 Mar 2021

Abstract excerpt

SARS-CoV-2 virus has infected more than 92 million people worldwide resulting in the Coronavirus disease 2019 (COVID-19). Using a rhesus macaque model of SARS-CoV-2 infection, we have characterized the transcriptional signatures induced in the lungs of juvenile and old macaques following infection. Genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are...

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PMID: 33674719
DOI: 10.1038/s42003-021-01829-4

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