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Article

A multiplier peroxiporin signal transduction pathway powers piscine spermatozoa

4 Mar 2021

Abstract excerpt

Significance Spermatozoon swimming performance is critical for fertilization success in fishes, yet the cellular mechanisms that regulate this vital trait are poorly understood. Here, we discovered that a water channel protein, acting as an H 2 O 2 channel (peroxiporin) to detoxify the mitochondria, directly regulates the velocity and progressive motility of both freshwater and marine spermatozoa. The...

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Share to Reproductive Biology and Fertility
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PMID: 33674382
DOI: 10.1073/pnas.2019346118

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