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A K+-selective CNG channel orchestrates Ca2+ signalling in zebrafish sperm

9 Dec 2015

Abstract excerpt

Calcium in the flagellum controls sperm navigation. In sperm of marine invertebrates and mammals, Ca(2+) signalling has been intensely studied, whereas for fish little is known. In sea urchin sperm, a cyclic nucleotide-gated K(+) channel (CNGK) mediates a cGMP-induced hyperpolarization that evokes Ca(2+) influx. Here, we identify in sperm of the freshwater fish Danio rerio a novel CNGK family member featuring...

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PMID: 26650356
DOI: 10.7554/elife.07624

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