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Germ–Somatic Cell Interactions Are Involved in Establishing the Follicle Reserve in Mammals

14 Jun 2021

Abstract excerpt

Mammalian females are born with a finite reserve of ovarian follicles, the functional units of the ovary. Building an ovarian follicle involves a complex interaction between multiple cell types, of which the oocyte germ cell and the somatic granulosa cells play a major role. Germ-somatic cell interactions are modulated by factors of different cell origins that influence ovarian development. In early development,...

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PMID: 34195191
DOI: 10.3389/fcell.2021.674137

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