Article
Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males.
EBioMedicine - 1 Mar 2021
Baldassarri Margherita, Picchiotti Nicola, Fava Francesca, Fallerini Chiara, Benetti Elisa, Daga Sergio, Valentino Floriana, Doddato Gabriella, Furini Simone, Giliberti Annarita, Tita Rossella, Amitrano Sara, Bruttini Mirella, Croci Susanna, Meloni Ilaria, Pinto Anna Maria, Iuso Nicola, Gabbi Chiara, Sciarra Francesca, Venneri Mary Anna, Gori Marco, Sanarico Maurizio, Crawley Francis P, Pagotto Uberto, Fanelli Flaminia, Mezzullo Marco, Dominguez-Garrido Elena, Planas-Serra Laura, Schlüter Agatha, Colobran Roger, Soler-Palacin Pere, Lapunzina Pablo, Tenorio Jair, Pujol Aurora, Castagna Maria Grazia, Marcelli Marco, Isidori Andrea M, Renieri Alessandra, Frullanti Elisa, Mari Francesca
Abstract excerpt
BACKGROUND: While SARS-CoV-2 similarly infects men and women, COVID-19 outcome is less favorable in men. Variability in COVID-19 severity may be explained by differences in the host genome. METHODS: We compared poly-amino acids variability from WES data in severely affected COVID-19 patients versus SARS-CoV-2 PCR-positive oligo-asymptomatic subjects. FINDINGS: Shorter polyQ alleles (≤22) in the androgen receptor...
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