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Article

Cell-assembled extracellular matrix (CAM) sheet production: Translation from using human to large animal cells

1 Jan 2021

Abstract excerpt

. A large animal TEVG would allow long-term pre-clinical studies in a clinically relevant setting (graft size and allogeneic setting). Therefore, canine, porcine, ovine, and human skin fibroblasts were compared for their ability to form CAM sheets. Serum sourcing greatly influenced CAM production in a species-dependent manner. Ovine cells produced the most homogenous and strongest animal CAM sheets but remained...

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PMID: 33633827
DOI: 10.1177/2041731420978327

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