Article
Assessing the Relationship Between High-sensitivity C-reactive Protein and Kidney Function Employing Mendelian Randomization in the Japanese Community-based J-MICC Study.
Journal of epidemiology - 5 Nov 2022
Fujii Ryosuke, Hishida Asahi, Nishiyama Takeshi, Nakatochi Masahiro, Matsuo Keitaro, Ito Hidemi, Nishida Yuichiro, Shimanoe Chisato, Nakamura Yasuyuki, Turin Tanvir Chowdhury, Suzuki Sadao, Watanabe Miki, Ibusuki Rie, Takezaki Toshiro, Mikami Haruo, Nakamura Yohko, Ikezaki Hiroaki, Murata Masayuki, Kuriki Kiyonori, Kuriyama Nagato, Matsui Daisuke, Arisawa Kokichi, Katsuura-Kamano Sakurako, Tsukamoto Mineko, Tamura Takashi, Kubo Yoko, Kondo Takaaki, Momozawa Yukihide, Kubo Michiaki, Takeuchi Kenji, Wakai Kenji
Abstract excerpt
BACKGROUND: Inflammation is thought to be a risk factor for kidney disease. However, whether inflammatory status is either a cause or an outcome of chronic kidney disease remains controversial. We aimed to investigate the causal relationship between high-sensitivity C-reactive protein (hs-CRP) and estimated glomerular filtration rate (eGFR) using Mendelian randomization (MR) approaches. METHODS: A total of 10,521...
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