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Article

Radiomics of Pediatric Low-Grade Gliomas: Toward a Pretherapeutic Differentiation of BRAF-Mutated and BRAF-Fused Tumors.

AJNR. American journal of neuroradiology - 1 Apr 2021

Wagner M W, Hainc N, Khalvati F, Namdar K, Figueiredo L, Sheng M, Laughlin S, Shroff M M, Bouffet E, Tabori U, Hawkins C, Yeom K W, Ertl-Wagner B B

Abstract excerpt

BACKGROUND AND PURPOSE: B-Raf proto-oncogene, serine/threonine kinase (BRAF) status has important implications for prognosis and therapy of pediatric low-grade gliomas. Currently, BRAF status classification relies on biopsy. Our aim was to train and validate a radiomics approach to predict BRAF fusion and BRAF V600E mutation. MATERIALS AND METHODS: In this bi-institutional retrospective study, FLAIR MR imaging...

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Identifiers

PMID: 33574103
DOI: 10.3174/ajnr.A6998
PMCID: PMC8040992

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