Multiclass Radiomics-Based Prediction of BRAF Mutation Status in Pediatric Low-grade Gliomas Using Multisequence MRI.

doi:10.3174/ajnr.A9296

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Article

Multiclass Radiomics-Based Prediction of BRAF Mutation Status in Pediatric Low-grade Gliomas Using Multisequence MRI.

AJNR. American journal of neuroradiology - 2 Sept 2026

Yahav-Dovrat Anat, Namdar Khashayar, Wagner Matthias W, Sheng Min, Naseri Mitra, Soldatelli Matheus D, Dirks Peter, Yeom Kristen W, Hawkins Cynthia, Eran Ayelet, Tabori Uri, Khalvati Farzad, Ertl-Wagner Birgit B

Abstract excerpt

BACKGROUND AND PURPOSE: Pediatric low-grade gliomas (pLGGs) are the most common brain tumors in children and frequently harbor BRAF alterations, most commonly KIAA1549-BRAF fusions and BRAF V600E mutations, which have distinct therapeutic implications. The aim of our study was to assess multiclass radiomics-based prediction of BRAF mutation status in children with pLGGs using multisequence MRI. This study follows...

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Topics

Humans
Radiomics
Glioma
Proto-Oncogene Proteins B-raf
Brain Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Child

Magnetic Resonance Imaging

Female

Retrospective Studies

Mutation

Male

Child, Preschool

Adolescent

Source

Open in PubMed Open full text

Identifiers

PMID: 41819797
DOI: 10.3174/ajnr.A9296
PMCID: PMC13537422

Genes

BRAF
KIAA1549

Variants

Provenance

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