Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis

Abstract excerpt

Bumped kinase inhibitors (BKIs) that target Cryptosporidium parvum calcium-dependent protein kinase 1 have been well established as potential drug candidates against cryptosporidiosis. Recently, BKI-1649, with a 7 H -pyrrolo[2,3- d ]pyrimidin-4-amine, or “pyrrolopyrimidine”, central scaffold, has shown improved efficacy in mouse models of Cryptosporidium at substantially reduced doses compared to previously...

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