Article
Investigation of gamma secretase gene complex mutations in German population with Hidradenitis suppurativa designate a complex polygenic heritage.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Jun 2021
Vural S, Baumgartner M, Lichtner P, Eckstein G, Hariry H, Chen W C, Ruzicka T, Melnik B, Plewig G, Wagner M, Giehl K A
Abstract excerpt
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting apocrine gland-bearing skin in the axilla, groin and under the breasts. Mutations of the gamma secretase gene complex, which is essential in the activation of Notch signalling pathways, were shown in some families with HS and in a few sporadic cases. Although an imbalance in Notch signalling is implicated in the pathogenesis,...
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