Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1-Mediated Secretion of Extracellular Vesicles.

doi:10.1158/0008-5472.CAN-20-2756

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Article

Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1-Mediated Secretion of Extracellular Vesicles.

Cancer research - 1 Apr 2021

Grunberg Nil, Pevsner-Fischer Meirav, Goshen-Lago Tal, Diment Judith, Stein Yaniv, Lavon Hagar, Mayer Shimrit, Levi-Galibov Oshrat, Friedman Gil, Ofir-Birin Yifat, Syu Li-Jyun, Migliore Cristina, Shimoni Eyal, Stemmer Salomon M, Brenner Baruch, Dlugosz Andrzej A, Lyden David, Regev-Rudzki Neta, Ben-Aharon Irit, Scherz-Shouval Ruth

Abstract excerpt

Gastric cancer is the third most lethal cancer worldwide, and evaluation of the genomic status of gastric cancer cells has not translated into effective prognostic or therapeutic strategies. We therefore hypothesize that outcomes may depend on the tumor microenvironment (TME), in particular, cancer-associated fibroblasts (CAF). However, very little is known about the role of CAFs in gastric cancer. To address...

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PMID: 33547159
DOI: 10.1158/0008-5472.CAN-20-2756
PMCID: PMC8337092

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