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Article

Inhibition of DHFR targets the self-renewing potential of brain tumor initiating cells

2 Feb 2021

Abstract excerpt

Brain tumors are a heterogeneous group of benign and malignant tumors arising from the brain parenchyma and its surrounding structures, with in general a poor clinical outcome due to high recurrence. One of the underlying causes for this somber prognostic is the presence of brain tumor initiating cells (BTIC) endowed with self-renewal potential, multi-lineage differentiation and resistance to treatment. One...

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PMID: 33545223
DOI: 10.1016/j.canlet.2021.01.026

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