Article
Excellent response to secukinumab in an infant with severe generalized pustular psoriasis.
The Journal of dermatology - 1 Jun 2021
López-Sánchez Cristina, Falla Lina María, Roé-Crespo Esther, Arostegui Juan Ignacio, Mozos Ana, Bernal Sara, Iznardo Helena, Baselga-Torres Eulalia
Abstract excerpt
Generalized pustular psoriasis (GPP) represents the rarest form of psoriasis, which may be potentially fatal. In the last decade, (likely) pathogenic variants in the IL36RN, CARD14 and AP1S3 genes have been associated with monogenic GPP forms. Despite these advances, the genetic basis of most patients with GPP remains unidentified. Treatment of GPP patients is often difficult, with no consensus about the best...
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