Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder.

Translational psychiatry - 2 Feb 2021

Burton Christie L, Lemire Mathieu, Xiao Bowei, Corfield Elizabeth C, Erdman Lauren, Bralten Janita, Poelmans Geert, Yu Dongmei, Shaheen S-M, Goodale Tara, Sinopoli Vanessa M, Soreni Noam, Hanna Gregory L, Fitzgerald Kate D, Rosenberg David, Nestadt Gerald, Paterson Andrew D, Strug Lisa J, Schachar Russell J, Crosbie Jennifer, Arnold Paul D

Abstract excerpt

Using a novel trait-based measure, we examined genetic variants associated with obsessive-compulsive (OC) traits and tested whether OC traits and obsessive-compulsive disorder (OCD) shared genetic risk. We conducted a genome-wide association analysis (GWAS) of OC traits using the Toronto Obsessive-Compulsive Scale (TOCS) in 5018 unrelated Caucasian children and adolescents from the community (Spit for Science...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Autism Spectrum Disorder Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Obsessive-Compulsive Disorder

Share to Obsessive-Compulsive Spectrum Disorders

Share to Phenotype

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 33531474
DOI: 10.1038/s41398-020-01121-9
PMCID: PMC7870035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study of pediatric obsessive-compulsive traits: shared genetic risk between traits and disorder.PMID 33531474Read ↗

Genome-wide Association Study of Pediatric Obsessive-Compulsive Traits: Shared Genetic Risk between Traits and DisorderSemantic proximity Read ↗

Polygenic risk scores for pediatric obsessive-compulsive symptoms: Mediating effects in samples clinically diagnosed with mental disorders.Semantic proximity Read ↗

Polygenic Risk Scores for Pediatric Obsessive-Compulsive Symptoms and their Mediating Effect in Clinically Diagnosed Samples of Obsessive-Compulsive Disorder, Attention-Deficit/Hyperactivity Disorder, Anxiety, Depression, Autism and Tic DisordersSemantic proximity Read ↗

Polygenic risk score and heritability estimates reveals a genetic relationship between ASD and OCD.Semantic proximity Read ↗

Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33 943 individuals from the general populationSemantic proximity Read ↗

Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population.Semantic proximity Read ↗

Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD.Semantic proximity Read ↗

Identifying risk loci for obsessive-compulsive disorder and shared genetic component with schizophrenia: A large-scale multi-trait association analysis with summary statistics.Semantic proximity Read ↗

Rare coding variation in OCD implicates shared genes with other psychiatric disordersSemantic proximity Read ↗

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture.Semantic proximity Read ↗

Genome-wide association study identifies new loci associated with OCDSemantic proximity Read ↗

Polygenic Risk Scores for Pediatric Obsessive-Compulsive Symptoms and their Mediating Effect in Clinically Diagnosed Samples of Obsessive-Compulsive Disorder, Attention-Deficit/Hyperactivity Disorder, Anxiety, Depression, Autism and Tourette syndromeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.