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Article

Diverse genetic backgrounds play a prominent role in the metabolic phenotype of CC021/Unc and CC027/GeniUNC mice exposed to inorganic arsenic.

Toxicology - 30 Mar 2021

Douillet Christelle, Ji Jinglin, Meenakshi Immaneni Lakshmi, Lu Kun, de Villena Fernando Pardo-Manuel, Fry Rebecca C, Stýblo Miroslav

Abstract excerpt

Arsenic methyltransferase (AS3MT) is the key enzyme in the pathway for the methylation of inorganic arsenic (iAs), a potent human carcinogen and diabetogen. AS3MT converts iAs to mono- and dimethylated arsenic species (MAs, DMAs) that are excreted mainly in urine. Polymorphisms in AS3MT is a key genetic factor affecting iAs metabolism and toxicity. The present study examined the role of As3mt polymorphisms in the...

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Identifiers

PMID: 33524430
DOI: 10.1016/j.tox.2021.152696
PMCID: PMC7914223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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