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Article

Detection of SARS-CoV-2 and Its Mutated Variants via CRISPR-Cas13-Based Transcription Amplification.

Analytical chemistry - 23 Feb 2021

Wang Yuxi, Zhang Yong, Chen Junbo, Wang Minjin, Zhang Ting, Luo Wenxin, Li Yalun, Wu Yangping, Zeng Bo, Zhang Kaixiang, Deng Ruijie, Li Weimin

Abstract excerpt

The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a global health emergency, and its gene mutation and evolution further posed uncertainty of epidemic risk. Herein, we reported a light-up CRISPR-Cas13 transcription amplification method, which enables the detection of SARS-CoV-2 and its mutated variants. Sequence specificity was ensured by both the ligation process and...

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PMID: 33511840
DOI: 10.1021/acs.analchem.0c04303

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