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A CRISPR-Cas12a-based specific enhancer for more sensitive detection of SARS-CoV-2 infection

9 Oct 2020

Abstract excerpt

BACKGROUND: Real-time reverse transcription-PCR (rRT-PCR) has been the most effective and widely implemented diagnostic technology since the beginning of the COVID-19 pandemic. However, fuzzy rRT-PCR readouts with high Ct values are frequently encountered, resulting in uncertainty in diagnosis. METHODS: A Specific Enhancer for PCR-amplified Nucleic Acid (SENA) was developed based on the Cas12a trans-cleavage...

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PMID: 33045467
DOI: 10.1016/j.ebiom.2020.103036

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