Article
Podocyte density is reduced in kidney allografts with high-risk APOL1 genotypes at transplantation.
Clinical transplantation - 1 Apr 2021
Chen Dhruti P, Zaky Ziad S, Schold Jesse D, Herlitz Leal C, El-Rifai Rasha, Drawz Paul E, Bruggeman Leslie A, Barisoni Laura, Hogan Susan L, Hu Yichun, O'Toole John F, Poggio Emilio D, Sedor John R
Abstract excerpt
Variants in apolipoprotein L1 (APOL1) gene are associated with nondiabetic kidney diseases in black subjects and reduced kidney transplant graft survival. Living and deceased black kidney donors (n = 107) were genotyped for APOL1 variants. To determine whether allografts from high-risk APOL1 donors have reduced podocyte densities contributing to allograft failure, we morphometrically estimated podocyte number,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.