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Article

Effect of Cetuximab-Conjugated Gold Nanoparticles on the Cytotoxicity and Phenotypic Evolution of Colorectal Cancer Cells.

Molecules (Basel, Switzerland) - 22 Jan 2021

El Hallal Ralph, Lyu Nana, Wang Yuling

Abstract excerpt

Epidermal growth factor receptor (EGFR) is estimated to be overexpressed in 60~80% of colorectal cancer (CRC), which is associated with a poor prognosis. Anti-EGFR targeted monoclonal antibodies (cetuximab and panitumumab) have played an important role in the treatment of metastatic CRC. However, the therapeutic response of anti-EGFR monoclonal antibodies is limited due to multiple resistance mechanisms. With the...

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PMID: 33499047
DOI: 10.3390/molecules26030567
PMCID: PMC7865832

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