Article
High genetic variability of Schmallenberg virus M-segment leads to efficient immune escape from neutralizing antibodies.
PLoS pathogens - 1 Jan 2021
Wernike Kerstin, Reimann Ilona, Banyard Ashley C, Kraatz Franziska, La Rocca S Anna, Hoffmann Bernd, McGowan Sarah, Hechinger Silke, Choudhury Bhudipa, Aebischer Andrea, Steinbach Falko, Beer Martin
Abstract excerpt
Schmallenberg virus (SBV) is the cause of severe fetal malformations when immunologically naïve pregnant ruminants are infected. In those malformed fetuses, a "hot-spot"-region of high genetic variability within the N-terminal region of the viral envelope protein Gc has been observed previously, and this region co-localizes with a known key immunogenic domain. We studied a series of M-segments of those SBV...
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