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Clinical and laboratory features of Hemoglobin La Desirade variant in association with sickle cell and alpha thalassemia genes

31 Dec 2020

Abstract excerpt

Abstract Hemoglobin La Desirade (Hb La Desirade) is an unstable hemoglobin variant characterized by amino acid Alanine (Ala) replacing Valine (Val) at position 129 (H7) in the beta chain. Hb La Desirade exhibits a decreased oxygen affinity and normal heme-heme interaction. Interestingly, on analysis by standard electrophoresis, it migrates in the same region as normal HbA, and HbA actually represents a...

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PMID: 33489049
DOI: 10.4084/mjhid.2021.010

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