Article
HbS-oman heterozygote: a new dominant sickle syndrome.
Blood - 1 Dec 1998
Nagel R L, Daar S, Romero J R, Suzuka S M, Gravell D, Bouhassira E, Schwartz R S, Fabry M E, Krishnamoorthy R
Abstract excerpt
Hemoglobin (Hb) S-Oman has two mutations in the beta-chains. In addition to the classic betaS mutation (beta6 Glu --> Val), it contains a second mutation in the same chain (beta121 Glu --> Lys) identical to that of HbOARAB. We have studied a pedigree of heterozygous carriers of HbS-Oman that segr...
Topics
- Adolescent
- Adult
- Anemia, Sickle Cell
- Child
- Female
- Hemoglobin, Sickle
- Hemoglobins, Abnormal
- Heterozygote
- Humans
- Male
- Mutation
- Pedigree
- Syndrome
- alpha-Thalassemia