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Article

Identification and validation of obesity-related gene LEP methylation as a prognostic indicator in patients with acute myeloid leukemia.

Clinical epigenetics - 23 Jan 2021

Zhang Ting-Juan, Xu Zi-Jun, Gu Yu, Ma Ji-Chun, Wen Xiang-Mei, Zhang Wei, Deng Zhao-Qun, Qian Jun, Lin Jiang, Zhou Jing-Dong

Abstract excerpt

BACKGROUND: Obesity confers enhanced risk for multiple diseases including cancer. The DNA methylation alterations in obesity-related genes have been implicated in several human solid tumors. However, the underlying role and clinical implication of DNA methylation of obesity-related genes in acute myeloid leukemia (AML) has yet to be elucidated. RESULTS: In the discovery stage, we identified that DNA...

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Share to DNA Methylation
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

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Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 33485366
DOI: 10.1186/s13148-021-01013-9
PMCID: PMC7824952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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