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Article

Analysis of the conformational changes caused by the mutations in mitofusin2 gene by Insilico approach.

JPMA. The Journal of the Pakistan Medical Association - 1 Dec 2020

Rasheed Muhammad Asif, Kanwal Sumaira, Jamil Farrukh, Ibrahim Muhammad, Perveen Shazia

Abstract excerpt

OBJECTIVE: To find the effect of pathogenic Mitofusin 2 mutations, responsible for Charcot-Marie-Tooth hereditary neuropathy type 2A, on protein structure. METHODS: The study was conducted at department of biosciences COMSATS University Islamabad, Sahiwal campus from September 2016 to July 2017, and comprised patients with Charcot Marie-Tooth hereditary neuropathy type 2A who were divided into early-onset severe...

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PMID: 33475540
DOI: 10.47391/JPMA.063

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