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Systematic comparison of high-throughput single-cell RNA-seq methods for immune cell profiling

20 Jan 2021

Abstract excerpt

BACKGROUND: Elucidation of immune populations with single-cell RNA-seq has greatly benefited the field of immunology by deepening the characterization of immune heterogeneity and leading to the discovery of new subtypes. However, single-cell methods inherently suffer from limitations in the recovery of complete transcriptomes due to the prevalence of cellular and transcriptional dropout events. This issue is...

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PMID: 33472597
DOI: 10.1186/s12864-020-07358-4

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