Article
A SNP in the Cache 1 Signaling Domain of Diguanylate Cyclase STM1987 Leads to Increased In Vivo Fitness of Invasive Salmonella Strains.
Infection and immunity - 17 Mar 2021
Sokaribo Akosiererem S, Balezantis Lindsay R, MacKenzie Keith D, Wang Yejun, Palmer Melissa B, Chung Beatrice, Herman Nancy J, McCarthy Madeline C, Chen Jeffrey M, White Aaron P
Abstract excerpt
Nontyphoidal Salmonella (NTS) strains are associated with gastroenteritis worldwide but are also the leading cause of bacterial bloodstream infections in sub-Saharan Africa. The invasive NTS (iNTS) strains that cause bloodstream infections differ from standard gastroenteritis-causing strains by >700 single-nucleotide polymorphisms (SNPs). These SNPs are known to alter metabolic pathways and biofilm formation and...
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