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Salmonella promotes virulence by repressing cellulose production.

Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2015

Pontes Mauricio H, Lee Eun-Jin, Choi Jeongjoon, Groisman Eduardo A

Abstract excerpt

Cellulose is the most abundant organic polymer on Earth. In bacteria, cellulose confers protection against environmental insults and is a constituent of biofilms typically formed on abiotic surfaces. We report that, surprisingly, Salmonella enterica serovar Typhimurium makes cellulose when inside macrophages. We determine that preventing cellulose synthesis increases virulence, whereas stimulation of cellulose...

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Adenosine Triphosphate
Cellulose
Glucosyltransferases
Intracellular Space
Macrophages

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Salmonella typhimurium

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PMID: 25848006
DOI: 10.1073/pnas.1500989112
PMCID: PMC4413311

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