Article
Molecular Epidemiological Analysis of the Origin and Transmission Dynamics of the HIV-1 CRF01_AE Sub-Epidemic in Bulgaria.
Viruses - 16 Jan 2021
Alexiev Ivailo, Campbell Ellsworth M, Knyazev Sergey, Pan Yi, Grigorova Lyubomira, Dimitrova Reneta, Partsuneva Aleksandra, Gancheva Anna, Kostadinova Asya, Seguin-Devaux Carole, Elenkov Ivaylo, Yancheva Nina, Switzer William M
Abstract excerpt
HIV-1 subtype CRF01_AE is the second most predominant strain in Bulgaria, yet little is known about the molecular epidemiology of its origin and transmissibility. We used a phylodynamics approach to better understand this sub-epidemic by analyzing 270 HIV-1 polymerase (pol) sequences collected from persons diagnosed with HIV/AIDS between 1995 and 2019. Using network analyses at a 1.5% genetic distance threshold...
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