Article
Association of high-risk neuroblastoma classification based on expression profiles with differentiation and metabolism.
PloS one - 1 Jan 2021
Kimura Shunsuke, Sekiguchi Masahiro, Watanabe Kentaro, Hiwatarai Mitsuteru, Seki Masafumi, Yoshida Kenichi, Isobe Tomoya, Shiozawa Yusuke, Suzuki Hiromichi, Hoshino Noriko, Hayashi Yasuhide, Oka Akira, Miyano Satoru, Ogawa Seishi, Takita Junko
Abstract excerpt
Neuroblastoma, the most common extracranial solid malignancy among children, originates from undifferentiated neural crest cells (NCC). Despite recent intensified treatment, high-risk patients still have a high mortality rate. To explore a new therapeutic strategy, we performed an integrated genomic and transcriptomic analysis of 30 high-risk neuroblastoma cases. Based on the expression profiling of RNA...
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