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Development and evaluation of a rapid and cost-efficient NGS-based MHC class I genotyping method for macaques by using a prevalent short-read sequencer.

Immunogenetics - 1 Apr 2021

Tanimoto Kousuke, Naruse Taeko K, Matano Tetsuro, Kimura Akinori

Abstract excerpt

Rhesus macaque is one of the most widely used primate model animals for immunological research of infectious diseases including human immunodeficiency virus (HIV) infection. It is well known that major histocompatibility complex (MHC) class I genotypes affect the susceptibility and disease progression to simian immunodeficiency virus (SIV) in rhesus macaques, which is resembling to HIV in humans. It is required...

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PMID: 33447871
DOI: 10.1007/s00251-020-01199-x

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