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Multiplex Detection of Clinically Relevant Mutations in Liquid Biopsies of Cancer Patients Using a Hybridization-Based Platform.

Clinical chemistry - 1 Mar 2021

Giménez-Capitán Ana, Bracht Jillian, García Juan José, Jordana-Ariza Núria, García Beatriz, Garzón Mónica, Mayo-de-Las-Casas Clara, Viteri-Ramirez Santiago, Martinez-Bueno Alejandro, Aguilar Andrés, Sullivan Ivana-Gabriela, Johnson Eric, Huang Chung-Ying, Gerlach Jay L, Warren Sarah, Beechem Joseph M, Teixidó Cristina, Rosell Rafael, Reguart Noemí, Molina-Vila Miguel A

Abstract excerpt

BACKGROUND: With the advent of precision oncology, liquid biopsies are quickly gaining acceptance in the clinical setting. However, in some cases, the amount of DNA isolated is insufficient for Next-Generation Sequencing (NGS) analysis. The nCounter platform could be an alternative, but it has never been explored for detection of clinically relevant alterations in fluids. METHODS: Circulating-free DNA (cfDNA) was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33439966
DOI: 10.1093/clinchem/hvaa248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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