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Article

Molecular screening of PROKR2 gene in girls with idiopathic central precocious puberty.

Italian journal of pediatrics - 7 Jan 2021

Aiello Francesca, Cirillo Grazia, Cassio Alessandra, Di Mase Raffaella, Tornese Gianluca, Umano Giuseppina R, Miraglia Del Giudice Emanuele, Grandone Anna

Abstract excerpt

BACKGROUND: Prokineticin receptor 2 (PROKR2) loss of function mutations have been described as cause of hypogonadotropic hypogonadism. In 2017, a first case of central precocious puberty (CPP) caused by PROKR2 heterozygous gain of function mutation was described in a 3.5 years-old girl. No other cases have been reported yet. This study performs a molecular screening in girls with early onset CPP (breast budding...

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Identifiers

PMID: 33413516
DOI: 10.1186/s13052-020-00951-z
PMCID: PMC7792053

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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