Article
Discovering and Visualizing Disease-Specific Electrocardiogram Features Using Deep Learning: Proof-of-Concept in Phospholamban Gene Mutation Carriers.
Circulation. Arrhythmia and electrophysiology - 1 Feb 2021
van de Leur Rutger R, Taha Karim, Bos Max N, van der Heijden Jeroen F, Gupta Deepak, Cramer Maarten J, Hassink Rutger J, van der Harst Pim, Doevendans Pieter A, Asselbergs Folkert W, van Es René
Abstract excerpt
BACKGROUND: ECG interpretation requires expertise and is mostly based on physician recognition of specific patterns, which may be challenging in rare cardiac diseases. Deep neural networks (DNNs) can discover complex features in ECGs and may facilitate the detection of novel features which possibly play a pathophysiological role in relatively unknown diseases. Using a cohort of PLN (phospholamban) p.Arg14del...
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