Article
Improving electrocardiogram-based detection of rare genetic heart disease using transfer learning: An application to phospholamban p.Arg14del mutation carriers.
Computers in biology and medicine - 1 Apr 2021
Lopes Ricardo R, Bleijendaal Hidde, Ramos Lucas A, Verstraelen Tom E, Amin Ahmad S, Wilde Arthur A M, Pinto Yigal M, de Mol Bas A J M, Marquering Henk A
Abstract excerpt
The pathogenic mutation p.Arg14del in the gene encoding Phospholamban (PLN) is known to cause cardiomyopathy and leads to increased risk of sudden cardiac death. Automatic tools might improve the detection of patients with this rare disease. Deep learning is currently the state-of-the-art in signal processing but requires large amounts of data to train the algorithms. In situations with relatively small amounts...
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