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Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing

12 Jun 2020

Abstract excerpt

Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular and cellular heterogeneity in GA using single-cell RNA sequencing (scRNA-seq). Design We performed unbiased transcriptome-wide scRNA-seq analysis on 27 677 cells from 9 tumour and 3 non-tumour samples. Analysis...

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PMID: 32532891
DOI: 10.1136/gutjnl-2019-320368

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